Konstantinos Chiotis, MD, PhD

Postdoc Scholar - Employee

Konstantinos is an attending neurologist, specializing in the care of patients with neurodegenerative disorders. He obtained his medical degree from the University of Patras in Greece (2011) and completed a Ph.D. at Karolinska Institutet (2013-2017), focusing on the development of multimodal neuroimaging biomarkers for Alzheimer’s disease at the Agneta Nordberg lab.

Currently serving as a postdoctoral fellow at the UCSF Memory and Aging Center in the RabLab, Konstantinos works on multimodal neuroimaging under the mentorship of Professor Gil Rabinovici and Dr. Renaud La Joie.

His primary interest lies in developing novel biomarkers to enhance the clinical management of patients with cognitive impairment and to identify new treatment targets. He aims to synthesize translational findings to unravel the complex and often heterogeneous cascade of events leading to neurodegeneration and cognitive impairment.

Publications: 

Tau PET positivity predicts clinically relevant cognitive decline driven by Alzheimer's disease compared to comorbid cases; proof of concept in the ADNI study.

Molecular psychiatry

Ioannou K, Bucci M, Tzortzakakis A, Savitcheva I, Nordberg A, Chiotis K, Alzheimer’s Disease Neuroimaging Initiative

Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach.

Methods in molecular biology (Clifton, N.J.)

Rodriguez-Vieitez E, Kumar A, Malarte ML, Ioannou K, Rocha FM, Chiotis K

Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer's disease with multi-modal PET and plasma GFAP.

Molecular neurodegeneration

Chiotis K, Johansson C, Rodriguez-Vieitez E, Ashton NJ, Blennow K, Zetterberg H, Graff C, Nordberg A

Profiling of plasma biomarkers in the context of memory assessment in a tertiary memory clinic.

Translational psychiatry

Bucci M, Bluma M, Savitcheva I, Ashton NJ, Chiotis K, Matton A, Kivipelto M, Di Molfetta G, Blennow K, Zetterberg H, Nordberg A

Astrocyte Signature in Alzheimer's Disease Continuum through a Multi-PET Tracer Imaging Perspective.

Cells

Fontana IC, Scarpa M, Malarte ML, Rocha FM, Ausellé-Bosch S, Bluma M, Bucci M, Chiotis K, Kumar A, Nordberg A

Blood β-synuclein is related to amyloid PET positivity in memory clinic patients.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Oeckl P, Bluma M, Bucci M, Halbgebauer S, Chiotis K, Sandebring-Matton A, Ashton NJ, Molfetta GD, Grötschel L, Kivipelto M, Blennow K, Zetterberg H, Savitcheva I, Nordberg A, Otto M

Crossover of Work Engagement: The Moderating Role of Agreeableness.

International journal of environmental research and public health

Chiotis K, Michaelides G

Correction to: The Strategic Biomarker Roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.

European journal of nuclear medicine and molecular imaging

Boccardi M, Dodich A, Albanese E, Gayet-Ageron A, Festari C, Ashton NJ, Bischof GN, Chiotis K, Leuzy A, Wolters EE, Walter M, Rabinovici GD, Carrillo M, Drzezga A, Hansson O, Nordberg A, Ossenkoppele R, Villemagne VL, Winblad B, Frisoni G, Garibotto V

Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline.

Molecular psychiatry

Bucci M, Chiotis K, Nordberg A, Alzheimer’s Disease Neuroimaging Initiative

Clinical validity of increased cortical binding of tau ligands of the THK family and PBB3 on PET as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.

European journal of nuclear medicine and molecular imaging

Chiotis K, Dodich A, Boccardi M, Festari C, Drzezga A, Hansson O, Ossenkoppele R, Frisoni G, Garibotto V, Nordberg A

Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Colato E, Chiotis K, Ferreira D, Mazrina MS, Lemoine L, Mohanty R, Westman E, Nordberg A, Rodriguez-Vieitez E, Alzheimer’s Disease Neuroimaging Initiative

Comparison of subtyping methods for neuroimaging studies in Alzheimer's disease: a call for harmonization.

Brain communications

Mohanty R, Mårtensson G, Poulakis K, Muehlboeck JS, Rodriguez-Vieitez E, Chiotis K, Grothe MJ, Nordberg A, Ferreira D, Westman E

[18F]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer's disease.

Molecular psychiatry

Chiotis K, Savitcheva I, Poulakis K, Saint-Aubert L, Wall A, Antoni G, Nordberg A

Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging.

European journal of nuclear medicine and molecular imaging

Murugan NA, Chiotis K, Rodriguez-Vieitez E, Lemoine L, Ågren H, Nordberg A

Clinical impact of [18F]flutemetamol PET among memory clinic patients with an unclear diagnosis.

European journal of nuclear medicine and molecular imaging

Leuzy A, Savitcheva I, Chiotis K, Lilja J, Andersen P, Bogdanovic N, Jelic V, Nordberg A

Optimal timing of tau pathology imaging and automatic extraction of a reference region using dynamic [18F]THK5317 PET.

NeuroImage. Clinical

Jonasson M, Wall A, Chiotis K, Leuzy A, Eriksson J, Antoni G, Nordberg A, Lubberink M

Tau PET imaging in neurodegenerative tauopathies-still a challenge.

Molecular psychiatry

Leuzy A, Chiotis K, Lemoine L, Gillberg PG, Almkvist O, Rodriguez-Vieitez E, Nordberg A

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.

European journal of nuclear medicine and molecular imaging

Leuzy A, Cicognola C, Chiotis K, Saint-Aubert L, Lemoine L, Andreasen N, Zetterberg H, Ye K, Blennow K, Höglund K, Nordberg A

Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer's disease.

European journal of nuclear medicine and molecular imaging

Carter SF, Chiotis K, Nordberg A, Rodriguez-Vieitez E

Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species.

NeuroImage. Clinical

Oliveira F, Leuzy A, Castelhano J, Chiotis K, Hasselbalch SG, Rinne J, Mendonça A, Otto M, Lleó A, Santana I, Johansson J, Anderl-Straub S, Arnim C, Beer A, Blesa R, Fortea J, Sanna-Kaisa H, Portelius E, Pannee J, Zetterberg H, Blennow K, Moreira AP, Abrunhosa A, Nordberg A, Castelo-Branco M

Spatial Normalization of 18F-Flutemetamol PET Images Using an Adaptive Principal-Component Template

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Lilja J, Leuzy A, Chiotis K, Savitcheva I, Sörensen J, Nordberg A

Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain.

European journal of nuclear medicine and molecular imaging

Chiotis K, Stenkrona P, Almkvist O, Stepanov V, Ferreira D, Arakawa R, Takano A, Westman E, Varrone A, Okamura N, Shimada H, Higuchi M, Halldin C, Nordberg A

Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding.

Alzheimer's & dementia (Amsterdam, Netherlands)

Lemoine L, Leuzy A, Chiotis K, Rodriguez-Vieitez E, Nordberg A

Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Leuzy A, Rodriguez-Vieitez E, Saint-Aubert L, Chiotis K, Almkvist O, Savitcheva I, Jonasson M, Lubberink M, Wall A, Antoni G, Nordberg A

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers.

The Lancet. Neurology

Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, Démonet JF, Garibotto V, Giannakopoulos P, Gietl A, Hansson O, Herholz K, Jack CR, Nobili F, Nordberg A, Snyder HM, Ten Kate M, Varrone A, Albanese E, Becker S, Bossuyt P, Carrillo MC, Cerami C, Dubois B, Gallo V, Giacobini E, Gold G, Hurst S, Lönneborg A, Lovblad KO, Mattsson N, Molinuevo JL, Monsch AU, Mosimann U, Padovani A, Picco A, Porteri C, Ratib O, Saint-Aubert L, Scerri C, Scheltens P, Schott JM, Sonni I, Teipel S, Vineis P, Visser PJ, Yasui Y, Winblad B

Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.

Neurobiology of aging

Chiotis K, Saint-Aubert L, Boccardi M, Gietl A, Picco A, Varrone A, Garibotto V, Herholz K, Nobili F, Nordberg A, Geneva Task Force for the Roadmap of Alzheimer's Biomarkers

Tau PET imaging: present and future directions.

Molecular neurodegeneration

Saint-Aubert L, Lemoine L, Chiotis K, Leuzy A, Rodriguez-Vieitez E, Nordberg A

A Cross-Validation of FDG- and Amyloid-PET Biomarkers in Mild Cognitive Impairment for the Risk Prediction to Dementia due to Alzheimer's Disease in a Clinical Setting.

Journal of Alzheimer's disease : JAD

Iaccarino L, Chiotis K, Alongi P, Almkvist O, Wall A, Cerami C, Bettinardi V, Gianolli L, Nordberg A, Perani D

Regional tau deposition measured by [18F]THK5317 positron emission tomography is associated to cognition via glucose metabolism in Alzheimer's disease.

Alzheimer's research & therapy

Saint-Aubert L, Almkvist O, Chiotis K, Almeida R, Wall A, Nordberg A

Comparability of [18F]THK5317 and [11C]PIB blood flow proxy images with [18F]FDG positron emission tomography in Alzheimer's disease.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Rodriguez-Vieitez E, Leuzy A, Chiotis K, Saint-Aubert L, Wall A, Nordberg A

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.

Brain : a journal of neurology

Leuzy A, Chiotis K, Hasselbalch SG, Rinne JO, de Mendonça A, Otto M, Lleó A, Castelo-Branco M, Santana I, Johansson J, Anderl-Straub S, von Arnim CA, Beer A, Blesa R, Fortea J, Herukka SK, Portelius E, Pannee J, Zetterberg H, Blennow K, Nordberg A

Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm.

European journal of nuclear medicine and molecular imaging

Chiotis K, Saint-Aubert L, Savitcheva I, Jelic V, Andersen P, Jonasson M, Eriksson J, Lubberink M, Almkvist O, Wall A, Antoni G, Nordberg A

Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Rodriguez-Vieitez E, Carter SF, Chiotis K, Saint-Aubert L, Leuzy A, Schöll M, Almkvist O, Wall A, Långström B, Nordberg A

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease.

Brain : a journal of neurology

Rodriguez-Vieitez E, Saint-Aubert L, Carter SF, Almkvist O, Farid K, Schöll M, Chiotis K, Thordardottir S, Graff C, Wall A, Långström B, Nordberg A

Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Jonasson M, Wall A, Chiotis K, Saint-Aubert L, Wilking H, Sprycha M, Borg B, Thibblin A, Eriksson J, Sörensen J, Antoni G, Nordberg A, Lubberink M

Amyloid PET in European and North American cohorts; and exploring age as a limit to clinical use of amyloid imaging.

European journal of nuclear medicine and molecular imaging

Chiotis K, Carter SF, Farid K, Savitcheva I, Nordberg A, Diagnostic Molecular Imaging (DiMI) network and the Alzheimer’s Disease Neuroimaging Initiative

Role of anthropometric characteristics in idiopathic carpal tunnel syndrome.

Archives of physical medicine and rehabilitation

Chiotis K, Dimisianos N, Rigopoulou A, Chrysanthopoulou A, Chroni E