Postdoc Scholar
M_Neuro-Memory and Aging
Jacob completed his doctoral work in Neuroscience in the Jagust lab at UC Berkeley, where he investigated the effects of network connectivity on Alzheimer’s pathology spread and cognitive aging. His research utilizes fMRI and PET imaging to study the biological substrates of changes in cognition.
As a postdoctoral fellow with Drs. Renaud La Joie and Gil Rabinovici at UCSF, Jacob works to unify measures of brain connectivity to uncover the biological features driving pathology spread in clinically heterogenous populations of neurodegenerative disease.
Publications
Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.
Cell reports
Connectivity, Pathology, and ApoE4 Interactions Predict Longitudinal Tau Spatial Progression and Memory.
Human brain mapping
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition.
Cerebral cortex (New York, N.Y. : 1991)
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.
bioRxiv : the preprint server for biology
Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tau pathology in cognitively normal older adults.
Alzheimer's & dementia (Amsterdam, Netherlands)