Hanna Cho describes the baseline cross-sectional data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS) cohort. All subjects were younger than 65 years old. 243/321 (76%) of the subjects with cognitive decline (Mild Cognitive Impairment or Dementia) were amyloid PET positive (refered on the paper as EOAD using Florbetaben and visual reads). 231/321 were both amyloid and tau PET positive (using Flortaucipir and quantification). Tau-PET signal was elevated across cortical regions with a parietal-predominant pattern, and higher burden was observed in younger and female EOAD participants.
Relevant manuscript investigating an understudied population like Early Onset Alzheimer's Disease. More papers coming up soon!
