Only a few months after she left the lab to start her PhD at UPenn, Xiuxiu got her first first author paper out! This is now available on pubmed and the Journal Of Nuclear Medicine wesbite.
In this paper, she evaluated how calibration sample size and PET image resolution affect the accuracy of Centiloid conversion for amyloid PET quantification. She found that reliable conversion can be achieved with as few as 15 Aβ-positive and 10 Aβ-negative scans, though increasing the number of Aβ-positive cases further reduced conversion error.
In addition, she identified that lower image resolution systematically underestimated Centiloid values, particularly in highly amyloid-positive scans. Despite these effects, errors around the 25 Centiloid cutoff used to define Aβ positivity remained minimal.
Congratulations to a major achievement (even more impressive given that Xiuxiu was only in the lab for 2 years!). And huge kudos to Ganna Blazhenets for her supervision on this project.
