I am a neuroradiologist–scientist with a special interest in biomarkers, and particularly imaging biomarkers in neurodegenerative diseases.
My research focuses on multi‑modal neuroimaging data, including structural MRI and brain molecular imaging such as FDG‑PET for metabolic activity, amyloid‑PET for amyloid pathology, and tau‑PET for tau pathology. I study patients across the spectrum of neurodegenerative disorders, including Alzheimer’s disease, FTLD, and Chronic Traumatic Encephalopathy.
In addition to imaging biomarkers, I have a strong clinical and research interest in amyloid‑targeting treatments and the imaging evaluation of ARIA, with a focus on improving safety monitoring and understanding treatment‑related changes.
My overarching goal is to use the unique in vivo window provided by advanced neuroimaging to better understand disease pathophysiology and to identify early, accurate, and biologically grounded imaging biomarkers that can improve diagnosis, staging, and therapeutic decision‑making.
Publications: https://www.ncbi.nlm.nih.gov/myncbi/orit.lesman.1/bibliography/public/