It is finally out!
After 2+ years of hard work gathering and curating datasets from around the world (53 studies from 15 countries), working on IRBs and data transfer agreements, and coming up with statistical models to analyze distributions and deriving thresholds, Ganna Blazhenets' paper is out in the Journal of the American Medical Association (JAMA): "Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer DiseaseAn Individual Participant Data Meta-Analysis".
We conducted this research to help determine robust Centiloid thresholds for all scientists and clinicians to use in their research studies and when diagnosing individuals in clinical settings. But this work really came together thanks to the incredible generosity of so many investigators who freely shared - and sometimes volunteered - their data to allow us to gather Centiloid values, a metric used to quantify amyloid PET signal, from 49 227 participants.
You can also check the accompanying JAMA editorial about our work, and the Alzforum article summarizing our main findings.
