Xiuxiu and Jhony presented posters about their ongoing work at the Bay Area Alzheimer's Disease Researcher Symposium 2024 at UC Davis.
Xiuxiu presented her work examining the variability in Centiloids conversion equations obtained from samples of varying sizes. She showed that amyloid-PET harmonization efforts would be improved by using larger validation datasets than the minimum recommended for CL calibration, as well as balanced sample sizes for the anchor points (Cognitively Normal and Alzheimer's groups) when calibrating the conversion equation.
Jhony presented his work aiming to image Chronic Traumatic Encephalopathy (CTE) In Vivo, in collaboration with Boston University and Life Molecular Imaging. He found that elevated [18F]PI-2620 binding may occur in participants with suspected CTE in the MTL, especially the entorhinal cortex. The results agree with post-mortem studies and prior studies with other tau PET tracers in suspected CTE. More cases of suspected CTE, matched controls, and subjects with Alzheimer’s Disease are needed to test the diagnostic potential of [18F]PI-2620 for CTE.
